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One trial had 71 women with mild to advanced signs of photoaging apply a facial cream containing GHK-Cu daily for three months and found that the treatment increased skin density and thickness while reducing sagging and the appearance of fine lines and wrinkles

What forms the bulk of the retail price2 of peptides is not the cost of manufacturing, but the capital infrastructure: the regulatory burden, the cold chain logistics, the pen device (which sometimes costs more than the drug itself), and, above all, the return needed to justify $9 billion in the initial R&D of these GLP-1 drugs

Women with a history of hormone-sensitive cancers on HRT for narrow indications require additional discussion before adding any peptide that elevates IGF-1

Berry et al., 2010)